This my Answer to the stackoverflow question: Best way to create a simple python web service:
Have a look at werkzeug. Werkzeug started as a simple collection of various utilities for WSGI applications and has become one of the most advanced WSGI utility modules. It includes a powerful debugger, full featured request and response objects, HTTP utilities to handle entity tags, cache control headers, HTTP dates, cookie handling, file uploads, a powerful URL routing system and a bunch of community contributed addon modules.
It includes lots of cool tools to work with http and has the advantage that you can use it with wsgi in different environments (cgi, fcgi, apache/mod_wsgi or with a plain simple python server for debugging).